eGFR (CKD-EPI 2021, race-free) Calculator

eGFR from creatinine, age, sex per CKD-EPI 2021 (Inker et al., NEJM). Race-free formula adopted by NKF/ASN.

Inputs

IDMS-traceable. Multiply µmol/L by 0.0113.

Result

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How to use this calculator

  • Enter serum creatinine (mg/dL; convert from µmol/L by × 0.0113).
  • Enter age and sex.
  • Read eGFR + KDIGO stage. Confirm diagnosis with second measurement.

About this calculator

CKD-EPI 2021 eGFR equation (Inker AS et al., "New Creatinine- and Cystatin C-Based Equations to Estimate GFR Without Race." NEJM 2021;385:1737-49). Race coefficient eliminated; endorsed by National Kidney Foundation + American Society of Nephrology Joint Task Force. KDIGO 2024 staging: G1 ≥90, G2 60-89, G3a 45-59, G3b 30-44, G4 15-29, G5 <15. Multiply µmol/L creatinine by 0.0113 for mg/dL. **Not medical advice — needs clinical context (proteinuria, BP, comorbidities).**

Frequently asked

Source of the formula?+
Inker AS et al., NEJM 2021;385:1737-49. The race-free CKD-EPI equation. Adopted by NKF/ASN Joint Task Force (recommendation September 2021).
Why no race coefficient?+
The race adjustment in the 2009 CKD-EPI equation introduced bias; NKF/ASN concluded a race-free equation is more equitable and equally accurate (Powe et al., NEJM 2021).
Cystatin C version?+
Inker 2021 also publishes eGFRcys and eGFRcr-cys equations using cystatin C (more accurate, less affected by muscle mass). Use when creatinine is unreliable (frail elderly, amputees).
When does eGFR underestimate?+
High muscle mass (bodybuilders), recent meat ingestion (acute creatinine bump), creatinine-secreting drugs (trimethoprim, cimetidine). Use cystatin C or 24-hr creatinine clearance.
KDIGO stages?+
G1 ≥90, G2 60-89, G3a 45-59, G3b 30-44, G4 15-29, G5 <15 mL/min/1.73 m². CKD requires reduced eGFR + abnormality (proteinuria, imaging, biopsy) sustained ≥3 months.
Is this medical advice?+
No. Educational. CKD diagnosis requires clinical correlation, urine albumin, and confirmation.

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